Dissolution Testing – Reconstitution and Solubility Validation
Dissolution testing is conducted on representative batches to assess compound solubility and reconstitution behavior in standard laboratory solvents such as bacteriostatic water, sterile saline, DMSO, and acetonitrile. This evaluation informs users of the most appropriate vehicle for their specific applications and is particularly critical for peptides that exhibit sequence-dependent solubility properties.
Solubility profiles are documented in technical data sheets or COAs when relevant, including notes on agitation requirements, pH adjustments, or heating protocols necessary for full dissolution. By validating reconstitution conditions, Pinnacle Compounds reduces waste, enhances reproducibility, and helps researchers avoid insoluble aggregates or bioavailability loss in sensitive assays.
Our multi-layered approach to ensuring research-grade excellence.
Mass Spectrometry (MS) verifies the molecular weight and structure of each compound. This ensures the product exactly matches its intended identity.
Using ICP-MS, we screen for heavy metals like lead and mercury. This ensures our compounds are free from toxic elements and meet safety standards.
This technique is particularly essential when dealing with structurally similar analogues, where minor sequence variations or stereochemical differences can alter pharmacological behavior.
To safeguard research integrity, particularly in applications involving injection, cell culture, or sensitive in vivo models, all applicable products undergo stringent sterility testing
Each finished unit undergoes dual-layer visual inspection prior to packaging. This includes human review under high-lux lighting and magnification
This evaluation informs users of the most appropriate vehicle for their specific applications and is particularly critical for peptides that exhibit sequence-dependent solubility properties
