Pesticide Screening

Multiresidue Analysis for Agricultural Contaminants

In recognition of increasing concerns regarding the inadvertent contamination of biologically derived materials and excipients with pesticide residues, Pinnacle Compounds screens relevant inputs using comprehensive multiresidue pesticide analysis. This testing employs LC-MS/MS and GC-MS to detect a panel of over 100 regulated pesticides, including organophosphates, carbamates, organochlorines, neonicotinoids, and pyrethroids. Materials of botanical or agricultural origin are particularly scrutinized to prevent residual agrochemical contamination, which could affect cellular signaling pathways, enzyme activity, or toxicological profiles in vitro or in vivo. All pesticides must be non-detectable or fall below maximum residue limits (MRLs) set by the U.S. Environmental Protection Agency (EPA) and the European Food Safety Authority (EFSA). These measures ensure that the integrity of bioassays and experimental reproducibility are not compromised by exogenous xenobiotics.

Related Quality Testing Protocol

Our multi-layered approach to ensuring research-grade excellence.

Purity – HPLC

Mass Spectrometry (MS) verifies the molecular weight and structure of each compound. This ensures the product exactly matches its intended identity.

Safety – Endotoxin Testing (LAL)

Bioburden testing measures microbial load before sterilization. This helps prevent contamination and ensures a clean, controlled research environment.

Heavy Metals Testing

Using ICP-MS, we screen for heavy metals like lead and mercury. This ensures our compounds are free from toxic elements and meet safety standards.

Mass Spectrometry (MS)

This technique is particularly essential when dealing with structurally similar analogues, where minor sequence variations or stereochemical differences can alter pharmacological behavior.

Sterility Testing

To safeguard research integrity, particularly in applications involving injection, cell culture, or sensitive in vivo models, all applicable products undergo stringent sterility testing

Visual Inspection

Each finished unit undergoes dual-layer visual inspection prior to packaging. This includes human review under high-lux lighting and magnification

Dissolution Testing

This evaluation informs users of the most appropriate vehicle for their specific applications and is particularly critical for peptides that exhibit sequence-dependent solubility properties